Lutein’s Protection Against Cisplatin’s Pulmonary Toxicity
DOI:
https://doi.org/10.5281/zenodo.15762202Anahtar Kelimeler:
Antioxidant, Cisplatin, Lutein, Lung, RatÖzet
One of the biggest problems of cancer treatment is the harmful effects of these drugs on the healthy tissues and organs of the organism. The aim is to determine the possible protective effects of Lutein (L) against Cisplatin (CS) toxicity in rat lungs by biochemical tests. In our study, lutein (L) (orally, 100 mg/kg) was administered for CS-induced lung toxicity (intraperitoneally (i.p.), 10 mg/kg). The study was completed with a total of 28 rats from 4 groups, each consisting of 7 subjects. Control, L, CS and CS + L. Lung damage induced by CS was a dose-limiting side effect of CS and caused an increase in PCO2 level and a decrease in PO2 and SaO2 levels. In our study, a significant decrease in PCO2 levels and an increase in SaO2 and PO2 levels were observed in L application (p< 0.05). In the CS + L group, there was an increase in CAT, SOD and GSH levels and a decrease in MDA levels compared to the CS group. A significant decrease in body weight was observed in the CS-treated group compared to the control. L supplementation in these rats caused a significant increase in body weight, bringing this value closer to normal (p< 0.05). It is understood from the study that L alleviates the results of oxidative stress, increases antioxidant functions and positively supports lung functions. It also demonstrates the ability of L to prevent CS-induced lung damage. Ultimately, L appears to be a applicable pharmacological agent in this injury.
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