Protectiveness of Lutein Against Cisplatin-Induced Pancreatic Toxicity
DOI:
https://doi.org/10.5281/zenodo.15107018Keywords:
Antioxidant, cisplatin, lutein, pancreasAbstract
Chemotherapy means using drugs to destroy cancer cells. This treatment can also damage normal healthy cells. This is the most important problem in drug-induced cancer treatment. Cisplatin (C) is in the structure of cis-diamine dichloroplatinum. In the study, the protection of lutein (L) (100mg/kg, oral) against damage caused by cisplatin (C) (10mg/kg, intraperitoneal (i.p.) was investigated. The study was conducted with 28 rats aged 9 weeks. Four groups were formed (n=7): Control, C, L and C + L. Biochemically, serum LP and AL levels were observed to be significantly increased in C compared to control (p<0.05). Serum AL and LP levels decreased significantly in the C + L group compared to the C group (p<0.05). In addition, an increase in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels and a decrease in malondialdehyde (MDA) levels were observed when compared to the C + L, C group (p<0.05). Antioxidant activity increased with the stimulation of L when compared to the C + L, C group. As a result, L; is effective against C-originated pancreatic toxicity. It has the potential to be used successfully in cases of damage to this organ.
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