THROMBOPHILIC GENE MUTATIONS IN PATIENTS WITH RECURRENT PREGNANCY LOSS

Abstract

Background: Recurrent pregnancy loss (RPL) is caused by different factors, including genetics and thrombophilia. FV LEIDEN, FVR 2, FXIII, ß-FIBRINOGEN , PROTROMBIN, PAI 1, HPA 1, MT 677, MT 1298, ACE, APO E, and APO B have been identified linking to hereditary thrombophilia. Objective: In this study, the effect of 12 factors, FV LEIDEN, FVR 2, FXIII, ß-FIBRINOGEN , PROTROMBIN, PAI 1, HPA 1, MT 677, MT 1298, ACE, APO E, and APO B are statistically evaluated in RPL patients data from recent articles. Materials and methods: In patients with recurrent miscarriage, the polymorphisms in which clotting factor genes were statistically analyzed. In addition, were discussed coagulation genes which relation to other diseases. Results: According to the studies related to this subject, FV LEIDEN (45%), PROTROMBIN (31%), FXIII (89%), ß-FIBRINOGEN (29%), PAI 1 (75%), MT 677 (44%) and MT 1298 (33%) were related to the abortions. Conclusion: Most commonly encounter mutations FV LEIDEN, FVR 2, MT 677, FXIII and ß- FIBRINOGEN genes similarly between country of the world. In this context, it may be useful in patients with RPL to monitor the clotting factors in order to clarify the cause of RPL.