Health Benefits of the Volatile Components of Black Seed (Nigella sativa) Analyzed by GC-MS

Özet

Black seed (Nigella sativa) is an annual herbaceous plant belonging to the Ranunculaceae family. The most commonly used part of the plant is its seeds, which are highly valued due to their chemical composition. In this study, the volatile components obtained from black seed (Nigella sativa) samples collected from the Amasya and Yozgat regions were analyzed. The obtained essential oils were analyzed using the GC-MS metod. According to the GC-MS analysis results, some volatile chemical compounds identified in black seed (Nigella sativa) and their potential applications in the health field are summarized below; Thymoquinone (p-cymene-2,5-dione) (% composition 11-15) : It has been shown to improve therapeutic indices when used in combination therapies with anticancer drugs and has contributed to preventing chemotherapy-induced damage in non-tumor tissues.Alpha-phellandrene (2-methyl-5-propan-2-ylcyclohexa-1,3-diene) ((%composition 3,4): Its essential oil exhibits antimicrobial activity and has been found effective against human breast cancer (Hs 578T) and prostate tumor (PC-3) cell lines. Beta-pinene (6,6-dimethyl-2-methylene-bicyclo[ 3.1.1]heptane) (%composition 0,03-0,07): Used as a natural insecticide and associated with certain biological activities; however, it has a high toxicity potential. Thymol (5-methyl-2-propan-2-ylphenol) (% composition 0,03-0,06): Utilized as an effective agent in reducing gingivitis and dental plaque formation. Limonene (1-methyl-4-prop-1-en-2-ylcyclohexene) (% composition 0,03): Animal studies have shown that it can slow the growth of various cancer cells such as those in the skin, lungs, stomach, and pancreas. However, there is still insufficient data to confirm these effects in humans.