Investigation of Anticancer, Antioxidant, and Phytochemical Properties of Cyperus esculentus Extracts Obtained Using Different Solvents
DOI:
https://doi.org/10.5281/zenodo.18000585Keywords:
cyperus esculantus, Anti-Cancer, AntioxidantAbstract
The chemical constituents of extracts from Cyperus esculantus were analyzed by GC-MS. Sixteen compounds were identified in the chloroform extract, accounting for 93.75% of the total oil that consisted mainly of hexadecanoic acid, methyl ester (CAS) (46,47%), 2(3H)-furanone, dihydro-3-(phenylmethyl)-(CAS) (24,60%). Seventeen compounds were identified methanol and hexan extract, accounting for 93.75% of the total oil that consisted mainly of respectively cheilanth-13(14)-enic methyl ester (12,03%), 1,4-benzenediol,2,5-bis(1,1-dimethylethyl) (10,20%), cholesta-9 (11), 20 (22)-dieene-3,23-dione, 6-hydroxy-5. Alpha, 6.alpha) (13,35%) and chlorhhiophps sulfoxide (11,83%). The extracts showed significant activities against the two "classical" cell lines DU-145 and PC-3 with X-chellingence. Chloroform, methanol, and hexan extracts against the DU-145 cell line with the IC50 values of 1,73461 g/mL, 101,409 μg/mL, and 32,146 μg/mL, respectively. Chloroform, methanol, and hexan extracts against the PC-3 cell line with the IC50 values of 1.222, 1.941, and 2.081 μg/mL, respectively. The antioxidant activity of Cyperus esculentus extracts obtained using various solvents was evaluated through different in vitro antioxidant assays. The methanol extract of Cyperus esculentus exhibited higher activity compared to the other extracts. Among the extracts, the chloroform extract showed the strongest DPPH scavenging activity.
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