Hirshfeld Surface Analysis and Intermolecular Interaction Profiling of Cyproheptadine Hydrochloride Sesquihydrate
DOI:
https://doi.org/10.5281/zenodo.17998151Anahtar Kelimeler:
Cyproheptadine hydrochloride, Hirshfeld surface analysis, crystal structure, Van der Waals interactionsÖzet
Cyproheptadine is a serotonin and histamine antagonist exhibiting notable anticholinergic and sedative properties. In the present study, Hirshfeld surface (HS) analysis and two-dimensional (2D) fingerprint plots were utilized to gain a deeper understanding of the intermolecular interactions governing the stability of the cyproheptadine hydrochloride sesquihydrate crystal. The HS analysis, performed using CrystalExplorer17.5, enabled visualization of interaction patterns within the crystal lattice through electron density partitioning, while the 2D fingerprint plots provided a quantitative assessment of atom–atom contact contributions. The findings demonstrate that hydrogen bonding interactions predominate and play a crucial role in maintaining the structural integrity and stability of the crystal, offering valuable insights for crystal engineering and pharmaceutical formulation studies.
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Telif Hakkı (c) 2025 EJONS Uluslararası Matematik, Mühendislik ve Doğa Bilimleri Dergisi
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