Synthesis and Characterization of Some Substituted Phenyl/Pyridin-4-yl Ring-Containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Compounds
DOI:
https://doi.org/10.5281/zenodo.18209758Keywords:
1 2 4-triazole, substituted aromatic carboxylic acids, phosphorus oxychloride, cyclization reactionsAbstract
In this study, six new compounds containing a 1,2,4-triazolo-thiadiazole structure were synthesized by reacting 4-amino-3-phenyl/(pyridin-4-yl)-5-mercapto-4H-1,2,4-triazole with carboxylic acids bearing different halogen and methyl substituents in the presence of phosphorus oxychloride. Phosphorus oxychloride is the effective reagent in the ring-closure reaction. The synthesized compounds were characterized using Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and electrospray ionization mass spectrometry analytical methods in order to determine their structural properties. The FTIR spectra provided information about the basic functional groups present in the compounds, the 1H-NMR spectra enabled a general structural evaluation of the proton environments, and the [M+H]+ molecular ions observed in the ESI-MS analyses enabled the determination of the molecular weights. The findings obtained from the applied analyses showed that the synthesized 1,2,4-triazolo-thiadiazole derivatives were formed appropriately.
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