SERUM ISCHEMIA-MODIFIED ALBUMIN AS AN OXIDATIVE STRESS BIOMARKER IN LUNG TUBERCULOSIS PATIENT
Ischemia-modified albumin in tuberculosis
DOI:
https://doi.org/10.5281/zenodo.7496483Keywords:
Tuberculosis, Oxidative stress, ischemia-modified albüminAbstract
Aim: The goal of this study was to investigate ischemia-modified albumin (IMA) as a novel marker of oxidative stress in tuberculosis patients.
Materials and methods: Our study included 49 patients with active lung tuberculosis and 45 healthy controls. Serum IMA was measured with automated spectrometric method and results were compared statistically.
Results: We found that IMA levels were significantly higher in pulmonary tuberculosis patients than in the control group. Albumin levels were significantly lower in the patient group than in the control group.
Conclusion: The study showed that we can use this parameter as a new oxidative stress marker in the pathogenesis of pulmonary tuberculosis.
References
World Health Organization. Global tuberculosis report 2019. Geneva, Switzerland: World Health Organization; 2019. https://www.who. int/tb/publi catio ns/global_repor t/en/
World Health Organization. Global tuberculosis report 2017. www. who.int/tb/publi catio ns/global_repor t/en/
Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury. Lab Invest. 1982; 47 (5): 412-26
Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med. 1991; 91(3C): 14-22
Chong WC, Shastri MD and Eri R. Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology. International Journal of Molecular Sciences. 2017; 18 (4): 771
Gundamaraju R, Vemuri R, Chong WC et al. Cell stress signaling cascades regulating cell fate. Curr Pharm Des 2018; 24 (27): 3176-3183. Doi: 10.2174/1381612824666180711122753
Cheresh P, Kim SJ, Tulasiram S et al. Oxidative stress and pulmonary fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013: 1832 (7): 1028–40
Marino E, Caruso M, Campagna D et al. Impact of air quality on lung health: myth or reality?. Therapeutic Advances in Chronic Disease. 2015; 6 (5): 286–98
Holguin F. Oxidative stress in airway diseases. Annals of the American Thoracic Society. 2013; 10: 150–7
Ingbar DH. Fishman’s pulmonary diseases and disorders. Annals of the American Thoracic Society. 2015; 12 (8): 1255-6
Nambi S, Long JE, Mishra BB et al. The oxidative stress network of Mycobacterium tuberculosis reveals coordination between radical detoxification systems. Cell Host & Microbe. 2015; 17 (6): 829–37
Oberley-Deegan RE, Rebits BW, Weaver MR, T et al. An oxidative environment promotes growth of Mycobacterium abscessus. Free Radical Biology and Medicine. 2010; 49 (11): 1666-73
Goyal N, Kashyap B, Singh N et al. Neopterin and oxidative stress markers in the diagnosis of extrapulmonary tuberculosis. Biomarkers. 2017; 22 (7): 648–53
Santus P, Corsico A, Solidoro P et al. Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. J Chron Obstruct Pulmon Dis. 2014; 11 (6): 705-17
Taverna M, Marie AL, Mira JP et al. Specific antioxidant properties of human serum albumin. Ann Intensive Care 2013; 3: 4
Bar-Or D, Curtis G, Rao N et al. Characterization of the Co (2+) and Ni (2+) binding amino acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem 2001; 268: 42-7
Apple FS. Clinical and analytical review of ischemia-modified albumin measured by the albumin cobalt binding test. Adv Clin Chem. 2005; 39: 1-10
Bar-Or D, Lau E,Winckler JV. A novel assay for cobalt-albumin binding and its potential as amarker ofmyocardial ischemia—a preliminary report. J EmergMed 2000; 19: 311–5
Lippi G, Montagnana M. Ischemia modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg 2009; 15: 137
Dundar ZD, Cander B, Gul M et al. Serum ischemia-modified albumin levels in an experimental acute mesenteric ischemia model. Acad Emerg Med. 2010; 17 (11): 1233-8
World Health Organization. Global tuberculosis report 2018 (Report No.: ISBN 978-92-4 156564-6).Geneva: WHO. 2018.http://www.who.int/tb/publi catio ns/global_repor t/en/
De Oliveira HG, Rossatto ER, Prolla JC. Pleural fluid adenosine deaminase and lymphocyte proportion: clinical usefulness in the diagnosis of tuberculosis, Cytopathology. 1994; 5 (1): 27-32
Kwiatkowska S, Piasecka G, Zieba M et al. Increased serum concentrations of conjugated diens and malondialdehyde in patients with pulmonary tuberculosis, Respiratory medicine. 1999; 93 (4): 272-6
Amaral EP, Conceicao EL, Costa DL et al. N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions. BMC Microbiol. 2016; 16: 251
Demir E, Giden R, Sak Zafer HA et al. Thiol‐disulphide homoeostasis as a novel oxidative stress biomarker in lung tuberculosis patient. Int J Clin Practice . 05 January 2021;e13998. https://doi.org/10.1111/ijcp.13998
Durak I, Canbolat O, Kavutçu M et al. Activities of total, cytoplasmic, and mitochondrial superoxide dismutase enzymes in sera and pleural fluids from patients with lung cancer, Journal of clinical laboratory analysisç. 1996; 10 (1): 17-20
Güney Y, Bilgihan A, Çiftçi TU et al. Serum Malondialdehyde Levels and Superoxide Dismutase Activities in Pulmonary Tuberculosis and Lung Cancers. Meslek Yuksekokulu Dergisi. 2004; 6: 33-8.
Reddy Y, Murthy SV, Krishna DR et al. Role of free radicals and antioxidants in tuberculosis patients. Indian J Tubercu. 2004; 51: 213-8
Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free RadicBiol Med 2013; 65: 244-53
Kaefer M, Piva SJ, De Carvalho JAM et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem 2010; 43: 450–4
Can U, Yerlikaya FH, Yosunkaya S. Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease. J Chin Med Assoc. 2015; 78 (12): 702-8
Kaplan M, Yuksel M, Ates I et al. Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases? J Gastroen Hepatol. 2016; 31 (6): 1120-5
Turedi S, Gunduz A, Mentese A et al. The value of ischemia-modified albumin in the diagnosis of pulmonary embolism. Am J Emerg Med. 2007; 25: 770-3
D'souza JM, Pai VR, Harish S et al. IMA and IMAR in serum andsaliva of preeclampsia a preliminary study. Hypertens Pregnancy 2014; 33: 440- 8
Bolatkale M, Duger M, Ülfer G et al. A novel biochemical marker for community-acquired pneumonia: ischemia-modified albumin. Am J Emerg Med. 2017; 35: 1121–5
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